Basic Information
VIS ID
TVIS44027645
Fusion event
HTLV-1-RHPN2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
q13.11
Reference genome
GRCh37/hg19
Start
33496056/33005150 (Hg38)
End
33496056/33005150 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
RHPN2
miRNAs that regulate target gene
hsa-mir-32-5p ; hsa-mir-100-5p ; hsa-mir-1273g-3p ; hsa-mir-1285-3p ; hsa-mir-196a-3p ; hsa-mir-3120-3p ; hsa-mir-3187-5p ; hsa-mir-451b ; hsa-mir-4696 ; hsa-mir-4793-3p ; hsa-mir-508-5p ; hsa-mir-5189-5p ; hsa-mir-612 ; hsa-mir-6512-3p ; hsa-mir-661 ; hsa-mir-6720-5p ; hsa-mir-6849-3p ; hsa-mir-6860 ; hsa-mir-766-3p ; hsa-mir-7703 ; hsa-mir-939-3p
Nearest miRNA
hsa-mir-10395/Upstream/12605796; hsa-let-7e/Downstream/2117550;
Nearest TSS
ENST00000633603/Upstream/8689; ENST00000592165/Downstream/22121;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/32748, chr19-CpG: 123/Downstream/59190
Upstream sequence
AGGGGACCAGGCTCACACATAAGATCTGAGTCATTCAGCAGTCCAGGGCTTTTCCCCTGGACCTCAAGAAAGATCTATTCTggccaggcgtggtggctca
Downstream sequence
tgcctctaatcccagcactttgggaggccgaggtgggcggatcacctgaggtcaggagttcaagaccagcctggccaacatggcaaaagcccatctctac
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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