Basic Information
VIS ID
TVIS44027670
Fusion event
HTLV-1-PPP1R13L integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
q13.32
Reference genome
GRCh37/hg19
Start
45906187/45402929 (Hg38)
End
45906187/45402929 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
PPP1R13L
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-184 ; hsa-mir-1249-5p ; hsa-mir-3714 ; hsa-mir-4419a ; hsa-mir-4510 ; hsa-mir-4747-5p ; hsa-mir-516b-5p ; hsa-mir-518c-5p ; hsa-mir-5196-5p ; hsa-mir-605-3p ; hsa-mir-6127 ; hsa-mir-6129 ; hsa-mir-6130 ; hsa-mir-6133 ; hsa-mir-6515-5p ; hsa-mir-6731-5p ; hsa-mir-6760-5p ; hsa-mir-6797-5p ; hsa-mir-6808-5p ; hsa-mir-6873-5p ; hsa-mir-6893-5p ; hsa-mir-8085 ; hsa-mir-873-5p ; hsa-mir-940 ; hsa-mir-9500
Nearest miRNA
hsa-mir-10395/Upstream/644208; hsa-let-7e/Downstream/33725;
Nearest TSS
ENST00000633603/Upstream/9762; ENST00000590794/Downstream/2109;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/4499, chr19-CpG: 24/Downstream/1953
Nearest cancer related gene
PPP1R13L(OG, No orient, 0)
Upstream sequence
ACCCCAGCCAGGTTCTTTAGGGCTAAGGATCCTGTGGACTTCCTGGAGGAGTCATCTTCAGTAGGAACCGGGTCagagagccagactgagctgggaacac
Downstream sequence
ccaggctggactcctacagccctgtcgggtcacactgaatctggagaggctccactgtctctgggactcggtttcctcctttgtggacgtctatggaatg
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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