Basic Information
VIS ID
TVIS44027679
Fusion event
HTLV-1-KLK11 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
q13.41
Reference genome
GRCh37/hg19
Start
51526010/51022754 (Hg38)
End
51526010/51022754 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
KLK11
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-10395/Upstream/1089617; hsa-let-7e/Downstream/184175;
Nearest TSS
ENST00000633603/Upstream/2579; ENST00000594910/Downstream/1457;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/3207, chr19-CpG: 25/Downstream/9208
Upstream sequence
CTTGAAGAGACTGGTTACAGACCAGAGGGCCCCCGGAGTCACCCTGGGCACGGGGAGAGAGAATGTCGGTCAGAGAAAGCGTTGAGCATGGTGTTAGCCA
Downstream sequence
GGGAGGAGGTGGGGACGGTGCTTAGGAGTGGGGCCGAGACAGGATGGGTAGGCACTGGGAAAGGTGATAGGTTTAGCGATAAAGCTGGGATTATGGGTGG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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