Basic Information
VIS ID
TVIS44027681
Fusion event
HTLV-1-IGLON5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
q13.41
Reference genome
GRCh37/hg19
Start
51823143/51319889 (Hg38)
End
51823143/51319889 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
IGLON5
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-574-3p ; hsa-mir-574-5p ; hsa-mir-147a ; hsa-mir-297 ; hsa-mir-6867-5p ; hsa-mir-644a ; hsa-mir-4711-3p ; hsa-mir-3911 ; hsa-mir-223-5p ; hsa-mir-567 ; hsa-mir-511-3p ; hsa-mir-3650 ; hsa-mir-7978 ; hsa-mir-138-5p ; hsa-mir-1281 ; hsa-mir-6836-3p ; hsa-mir-5001-3p ; hsa-mir-4279 ; hsa-mir-6881-3p ; hsa-mir-6780a-3p ; hsa-mir-7111-3p ; hsa-mir-6829-3p ; hsa-mir-6791-3p ; hsa-mir-6778-3p ; hsa-mir-942-5p ; hsa-mir-877-3p ; hsa-mir-6769b-3p ; hsa-mir-4723-3p ; hsa-mir-3183 ; hsa-mir-660-3p ; hsa-mir-5193
Nearest miRNA
hsa-mir-10395/Upstream/112880; hsa-let-7e/Downstream/372723;
Nearest TSS
ENST00000633603/Upstream/8041; ENST00000601148/Downstream/19866;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/7685, chr19-CpG: 86/Downstream/6921
Upstream sequence
TACACACCTGTCCCTCTGAGCGGGTCCACAGCCATGCGCGTGACTGAGAGGGTGGGACTGTCTCCtgtgtttgtatgcgtgtgattgtatgtgtttgtgt
Downstream sequence
gtgtgtgtgtatgggtgtAGCTGGAGCTGTTTGTGTCTGTATGACTGTGTCTGTACCTCTCTGTCTGGGTAAGGACATAGCAAGTGTGGGGACTATTTCT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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