Basic Information
VIS ID
TVIS44027683
Fusion event
HTLV-1-TTYH1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
q13.42
Reference genome
GRCh37/hg19
Start
54939679/54428501 (Hg38)
End
54939679/54428501 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
TTYH1
miRNAs that regulate target gene
hsa-mir-186-5p ; hsa-mir-3133 ; hsa-mir-4520-2-3p ; hsa-mir-4529-3p ; hsa-mir-4535 ; hsa-mir-4663 ; hsa-mir-4776-5p ; hsa-mir-511-5p ; hsa-mir-628-5p ; hsa-mir-6830-3p ; hsa-mir-6846-3p ; hsa-mir-711 ; hsa-mir-7160-5p ; hsa-mir-7850-5p ; hsa-mir-8077 ; hsa-mir-9-5p
Nearest miRNA
hsa-let-7e/Upstream/146321; hsa-mir-10394/Downstream/216808;
Nearest TSS
ENST00000633603/Upstream/2027; ENST00000476863/Downstream/2312;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/11450, chr19-CpG: 93/Downstream/20512
Upstream sequence
tttttgtagagatggagtcttgctatgttgcccaggctggtctcgaactcctggcctcaagtgatcagcctgcctcagccttccaaagtactgggtttac
Downstream sequence
aggcatgagctaccatgcctggcccttctccctgtttaacagagggagagactgaagatcagagaggttggaccacttgctcagggccacacagctagaa
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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