Basic Information
VIS ID
TVIS44027702
Fusion event
HTLV-1-SPTLC3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr20
Cytoband
p12.1
Reference genome
GRCh37/hg19
Start
12994104/13013456 (Hg38)
End
12994104/13013456 (Hg38)
Orient
+
Location type
Intronic
Target gene
SPTLC3
miRNAs that regulate target gene
hsa-mir-21-5p ; hsa-mir-8064 ; hsa-mir-4643 ; hsa-mir-8485 ; hsa-mir-642b-3p ; hsa-mir-642a-3p ; hsa-mir-662 ; hsa-mir-7977 ; hsa-mir-24-3p ; hsa-mir-4284 ; hsa-mir-564 ; hsa-mir-4650-5p ; hsa-mir-1972 ; hsa-mir-383-3p ; hsa-mir-506-5p ; hsa-mir-4262 ; hsa-mir-181d-5p ; hsa-mir-181c-5p ; hsa-mir-181b-5p ; hsa-mir-181a-5p ; hsa-mir-544a ; hsa-mir-122-5p ; hsa-mir-504-3p ; hsa-mir-891b ; hsa-mir-8082 ; hsa-mir-4534 ; hsa-mir-2276-3p ; hsa-mir-4772-3p ; hsa-mir-6514-5p ; hsa-mir-613 ; hsa-mir-206 ; hsa-mir-1-3p ; hsa-mir-106a-3p ; hsa-mir-1247-3p ; hsa-mir-3689d ; hsa-mir-377-5p ; hsa-mir-4537 ; hsa-mir-4684-3p ; hsa-mir-6086 ; hsa-mir-6134 ; hsa-mir-6799-5p ; hsa-mir-6851-5p ; hsa-mir-6880-5p ; hsa-mir-7161-3p ; hsa-mir-7847-3p
Nearest miRNA
hsa-mir-103a-2/Upstream/2363761; hsa-mir-1-1/Downstream/5457159;
Nearest TSS
ENST00000382410/Upstream/4107; ENST00000485952/Downstream/113190;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/1121897, chr20-CpG: 217/Downstream/206567
Upstream sequence
CAGCCGTGGTAAGTACCTGTGTCTGTGGGGCTCACCTAGGCTACCCCCTGATTGAAATAGAGGTCAATATTCTCTCCAATTACTAGGAGAATTCATAAAC
Downstream sequence
TAAAAGTTTTGGAAATCCCTTTCAACTGCTCTGAGTCTTCATCTTAGTCTTGTCTTTGGTGTTCATTTTCTAATGCCTTTGTTTCTTGGCTCCTATTTCC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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