Basic Information
VIS ID
TVIS44027717
Fusion event
HTLV-1-RALGAPA2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr20
Cytoband
p11.23
Reference genome
GRCh37/hg19
Start
20637044/20656400 (Hg38)
End
20637044/20656400 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA20A
Target gene
RALGAPA2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-let-7c-5p ; hsa-mir-6763-5p ; hsa-mir-3150a-3p ; hsa-mir-491-5p ; hsa-mir-6825-5p ; hsa-mir-92a-2-5p ; hsa-mir-939-5p ; hsa-mir-1343-5p ; hsa-mir-3175 ; hsa-mir-3616-3p ; hsa-mir-576-5p ; hsa-mir-4263 ; hsa-mir-627-3p
Nearest miRNA
hsa-mir-103a-2/Upstream/2185709; hsa-mir-1-1/Downstream/5551786;
Nearest TSS
ENST00000382410/Upstream/15594; ENST00000432942/Downstream/56088;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/203715, chr20-CpG: 106/Downstream/55704
Upstream sequence
AACATTTACGAGTATTTATATGCACAACTAGTTCTAAAAAGTTAAACATATTAGAAAATGTGGGGAAATTGATGTCACATAACAGAATGACTTCAATATT
Downstream sequence
AAATAAAGTGAGCTCAATATTAATCTCTTGCCTTGAGAACACACAACCTTTGTAAGCCAGACACCAAATGCCAGGCATGACAGATCCATCTATAAATTGT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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