Basic Information
VIS ID
TVIS44027734
Fusion event
HTLV-1-DNMT3B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr20
Cytoband
q11.21
Reference genome
GRCh37/hg19
Start
31383715/32795909 (Hg38)
End
31383715/32795909 (Hg38)
Orient
+
Location type
Intronic
Target gene
DNMT3B
miRNAs that regulate target gene
hsa-mir-148a-3p ; hsa-mir-29c-3p ; hsa-mir-29b-3p ; hsa-mir-29a-3p ; hsa-mir-369-5p ; hsa-mir-335-5p ; hsa-mir-375 ; hsa-mir-93-5p ; hsa-mir-200b-3p ; hsa-mir-200c-3p ; hsa-mir-26a-5p ; hsa-mir-124-3p ; hsa-mir-506-3p ; hsa-mir-29c-5p
Nearest miRNA
hsa-mir-103a-2/Upstream/558062; hsa-mir-1-1/Downstream/1253210;
Nearest TSS
ENST00000382410/Upstream/16057; ENST00000375571/Downstream/23984;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/32452, chr20-CpG: 84/Downstream/23816
Nearest cancer related gene
DNMT3B(TSG, No orient, 0)
Upstream sequence
TCAGGCCAAGGCCTATTTCTGGACCCTGCATCTTAGTTGCTAGTTTATGGAATGAGTTGCCAATTGTGCCCCTTAAGAGAAAGGTACAGGAAGGGTATGG
Downstream sequence
TGAGGAACAAGGGAAGCTGGGCCATTTTGGCCGGGAGAGCCATAACCTAAAACCAAGATTACTGGTATCATGAACCTTCCCAAAGAAGAACTGCAACTAA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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