Basic Information
VIS ID
TVIS44027814
Fusion event
HTLV-1-PLCB4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr20
Cytoband
p12.2
Reference genome
GRCh37/hg19
Start
9321831/9341184 (Hg38)
End
9321831/9341184 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA20B
Target gene
PLCB4
miRNAs that regulate target gene
hsa-mir-9-5p ; hsa-mir-26b-5p ; hsa-mir-412-3p ; hsa-mir-371a-3p
Nearest miRNA
hsa-mir-103a-2/Upstream/1969492; hsa-mir-1-1/Downstream/1308452;
Nearest TSS
ENST00000382410/Upstream/33384; ENST00000464199/Downstream/29750;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/271813, chr20-CpG: 32/Downstream/165280
Upstream sequence
gcacccactttgcTCTGTGCCCTGAGCAAATACAGTCCTGGGGAGATGGCTCAAATCAGTAAATCCCATAATGTTTTTGCTTTCCATAATTTGGTTGCTG
Downstream sequence
TTAGTCTTGGCCCATTCTAAGAACCACGTTCTGAAACATACCCTTGAGTAGATTATGGATGTGTACTgttggcccttgaacaatgtgggggttagagcta
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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