Basic Information
VIS ID
TVIS44027845
Fusion event
HTLV-1-TIAM1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr21
Cytoband
q22.11
Reference genome
GRCh37/hg19
Start
32654665/31282350 (Hg38)
End
32654665/31282350 (Hg38)
Orient
+
Location type
Intronic
Target gene
TIAM1
miRNAs that regulate target gene
hsa-mir-21-5p ; hsa-mir-31-5p ; hsa-mir-335-5p ; hsa-mir-744-5p ; hsa-mir-93-3p ; hsa-mir-769-3p ; hsa-mir-615-3p ; hsa-mir-221-3p ; hsa-let-7b-5p ; hsa-mir-10b-5p ; hsa-mir-329-3p ; hsa-mir-141-3p ; hsa-mir-10a-5p ; hsa-mir-342-3p ; hsa-mir-29c-3p ; hsa-mir-22-3p ; hsa-mir-182-5p
Nearest miRNA
hsa-let-7c/Upstream/906972; hsa-mir-3197/Downstream/2268312;
Nearest TSS
ENST00000624081/Upstream/121441; ENST00000433071/Downstream/61929;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/30284, chr21-CpG: 40/Downstream/61379
Upstream sequence
tatgatgagcaatgctctagacctcatccttccacggaggctcagtgacaaatttcataggaatgtttcttgtcttgaAAATTATTTTTTTAAAAACCGC
Downstream sequence
AATTCAGCAGCAAGCAGCCGTCTTGAAGACGCAGGATACTGCTGCAGAGTGGACAGACAGTGTTCCTTCCAGGAAATTCTTCTTGAGCACTGCCTGCCCT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate