Basic Information
VIS ID
TVIS44027861
Fusion event
HTLV-1-PRDM15 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr21
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
43242211/41821855 (Hg38)
End
43242211/41821855 (Hg38)
Orient
+
Location type
Intronic
Target gene
PRDM15
miRNAs that regulate target gene
hsa-mir-587 ; hsa-mir-583 ; hsa-mir-1276 ; hsa-mir-4311 ; hsa-mir-3187-3p ; hsa-mir-4435 ; hsa-mir-588 ; hsa-mir-4701-5p ; hsa-mir-548s ; hsa-mir-4529-5p ; hsa-mir-4635 ; hsa-mir-212-3p ; hsa-mir-132-3p
Nearest miRNA
hsa-let-7c/Upstream/75014; hsa-mir-5692b/Downstream/1129073;
Nearest TSS
ENST00000624081/Upstream/2072; ENST00000458654/Downstream/13663;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/1625, chr21-CpG: 18/Downstream/26
Nearest cancer related gene
PRDM15(OG, No orient, 0)
Upstream sequence
CTGCAGTAGGACCACTGGCCGGAGCCTTTGGGGAGGGAGGGCTGCTTCCGAGATGCATGAAGGTGCCTGCTGTGTGGGGCCCACAGCCTTGAAACGACCA
Downstream sequence
CCTTCCTCTCCAGACCACCCAGGCACCGCGGGGCAAACCCGCCATACCTGGCACCGCTTGCAGCTGTACTTGTGAGGCTCCGAGTCTGCGCTCTCGTCAG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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