Basic Information
VIS ID
TVIS44027908
Fusion event
HTLV-1-HORMAD2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q12.2
Reference genome
GRCh37/hg19
Start
30561728/30165739 (Hg38)
End
30561728/30165739 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA22B
Target gene
HORMAD2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-580-3p ; hsa-mir-7153-5p ; hsa-mir-103a-2-5p ; hsa-mir-146b-5p ; hsa-mir-146a-5p ; hsa-mir-589-5p
Nearest miRNA
hsa-mir-1286/Upstream/158626; hsa-let-7a-3/Downstream/565818;
Nearest TSS
ENST00000624155/Upstream/71781; ENST00000447565/Downstream/41370;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/85198, chr22-CpG: 19/Downstream/78001
Upstream sequence
ttaataGATTTGTAGTTTGGGTTTACATATTTGTTTCCTTAAGTTAGCTGGGATATTTCCCCCAGTATGATAACTTTTTCCCATTTTATTGGTACCACCT
Downstream sequence
GAATAGTCTGCCAATTCCCTGGTAattgaaatgccacctttttcataaaccatagcataggtttgtttttagatttttctcttctatttcactgatccat
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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