Basic Information
VIS ID
TVIS44027932
Fusion event
HTLV-1-SCUBE1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
43647678/43251672 (Hg38)
End
43647678/43251672 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA22A
Target gene
SCUBE1
miRNAs that regulate target gene
hsa-mir-4420 ; hsa-mir-450a-1-3p ; hsa-mir-181b-3p ; hsa-mir-181b-2-3p ; hsa-mir-5196-5p ; hsa-mir-4747-5p ; hsa-mir-671-5p ; hsa-mir-4786-3p ; hsa-mir-3189-3p ; hsa-mir-34c-3p ; hsa-mir-449b-3p
Nearest miRNA
hsa-mir-1281/Upstream/1328375; hsa-let-7a-3/Downstream/1949282;
Nearest TSS
ENST00000624155/Upstream/19531; ENST00000458463/Downstream/11127;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/41442, chr22-CpG: 218/Downstream/90670
Upstream sequence
gactggggcgggtcaggctgctggctctgcaggtggagaagggaccgcgggacaaggaacgtgggcagctctagaagctggaaaggcaaggaaggggatg
Downstream sequence
cacccctggagcctccagaaggaaacagccctgccgacatcttcaatttagcccagtgagccccaggtcaaatttctgacctacagaagataataaacgt
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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