Basic Information
VIS ID
TVIS44027934
Fusion event
HTLV-1-SHISAL1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q13.31
Reference genome
GRCh37/hg19
Start
44671400/44275520 (Hg38)
End
44671400/44275520 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA22A
Target gene
SHISAL1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-26b-5p ; hsa-mir-1226-3p ; hsa-mir-218-5p ; hsa-mir-7855-5p ; hsa-mir-4710 ; hsa-mir-504-3p ; hsa-mir-4792 ; hsa-mir-6778-3p ; hsa-mir-6133 ; hsa-mir-6130 ; hsa-mir-6129 ; hsa-mir-6127 ; hsa-mir-4510 ; hsa-mir-6873-5p ; hsa-mir-4419a ; hsa-mir-6856-5p ; hsa-mir-6758-5p ; hsa-mir-510-3p ; hsa-mir-502-5p ; hsa-mir-7162-5p ; hsa-mir-516b-3p ; hsa-mir-516a-3p ; hsa-mir-2115-5p ; hsa-mir-6776-3p ; hsa-mir-497-3p
Nearest miRNA
hsa-mir-1281/Upstream/2352223; hsa-let-7a-3/Downstream/925434;
Nearest TSS
ENST00000624155/Upstream/46008; ENST00000406912/Downstream/37331;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/250610, chr22-CpG: 154/Downstream/55216
Upstream sequence
AGCTCCTGGGCCCAGACCAGAGAGGACTTGTTTCACTGACACCTGTGGGCCAGATCTCAGGTGCTTTGGGGGACCCCTGAGGTCCTGCCTGGGGGATGGG
Downstream sequence
TGAGGCCTACCTTGCACAGAGAACCCACAACCATAAGGCAGCTATGCAGCCGGCATGGGGTGGCATTATCTCAGGGTTAGCTCTTACAGGAAGCGAAGTA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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