Basic Information
VIS ID
TVIS44027961
Fusion event
HTLV-1-PAK3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
q23
Reference genome
GRCh37/hg19
Start
110395185/111151957 (Hg38)
End
110395185/111151957 (Hg38)
Orient
+
Location type
Intronic
Target gene
PAK3
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-3149 ; hsa-mir-6855-5p ; hsa-mir-3170 ; hsa-mir-4684-5p ; hsa-mir-411-5p ; hsa-mir-6832-5p ; hsa-mir-193b-5p ; hsa-mir-1273f ; hsa-mir-4781-3p ; hsa-mir-6890-5p ; hsa-mir-4762-5p ; hsa-mir-3613-3p ; hsa-mir-3074-3p ; hsa-mir-7-2-3p ; hsa-mir-7-1-3p ; hsa-mir-506-3p ; hsa-mir-6744-3p ; hsa-mir-124-3p ; hsa-mir-4757-5p ; hsa-mir-6758-3p ; hsa-mir-6769b-3p ; hsa-mir-4723-3p ; hsa-mir-3183 ; hsa-mir-4698 ; hsa-mir-8063 ; hsa-mir-2278 ; hsa-mir-4753-5p ; hsa-mir-4713-5p ; hsa-mir-582-5p ; hsa-mir-101-3p ; hsa-mir-2116-3p ; hsa-mir-532-3p ; hsa-mir-150-5p ; hsa-mir-6877-3p ; hsa-mir-6819-3p ; hsa-mir-7109-3p
Nearest miRNA
hsa-let-7f-2/Upstream/1069739; hsa-mir-105-1/Downstream/1628761;
Nearest TSS
ENST00000429181/Upstream/9814; ENST00000563467/Downstream/118566;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/55506, chrX-CpG: 22/Downstream/472286
Upstream sequence
aactggctattaagtgactaataggctggtagtgtaaacagagtaggtacactggacaaagggatgattcacatttcaggtggaatggagcaggaccgcg
Downstream sequence
tgagattttatcatactcagaatggcatgcagtttgaaactcatgaattggttatttctgcaatttttgatgtaatatttttgaaccacagttgaccaca
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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