Basic Information
VIS ID
TVIS44027970
Fusion event
HTLV-1-PLS3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
q23
Reference genome
GRCh37/hg19
Start
114816266/115581952 (Hg38)
End
114816266/115581952 (Hg38)
Orient
+
Location type
Intronic
Target gene
PLS3
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-148b-5p ; hsa-mir-193b-3p ; hsa-mir-320a ; hsa-mir-125a-5p ; hsa-mir-186-5p ; hsa-mir-6507-5p ; hsa-mir-3653-3p ; hsa-mir-3658 ; hsa-mir-218-5p
Nearest miRNA
hsa-let-7f-2/Upstream/758388; hsa-mir-105-1/Downstream/2804442;
Nearest TSS
ENST00000429181/Upstream/19221; ENST00000473026/Downstream/11601;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/19630, chrX-CpG: 68/Downstream/143456
Upstream sequence
GCAGAATTACTTCTATAAAGAAAACTTCCCTAAGTTACAGCATCTGGCTCATAGCATTATCATTACAGTGAAGTTTACCATCACTCATATTAGTGATGTG
Downstream sequence
TTACTTCCCACTTACTCCTAACCCTGCTTAGGTAATGCAAAACTATAATTTAGAAAGTGTGATTTAAAGAAGATGCAATATAATGGTACTCATTGTAAAC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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