Basic Information
VIS ID
TVIS44027987
Fusion event
HTLV-1-APLN integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
q26.1
Reference genome
GRCh37/hg19
Start
128781668/129647691 (Hg38)
End
128781668/129647691 (Hg38)
Orient
+
Location type
UTR3
Target gene
APLN
miRNAs that regulate target gene
hsa-mir-30b-5p ; hsa-mir-30c-5p ; hsa-mir-629-3p ; hsa-mir-6867-3p ; hsa-mir-4713-5p ; hsa-mir-6734-3p ; hsa-mir-4662a-5p ; hsa-mir-6756-3p ; hsa-mir-3127-3p ; hsa-mir-361-3p ; hsa-mir-6729-3p ; hsa-mir-4286 ; hsa-mir-224-5p ; hsa-mir-125b-5p ; hsa-mir-1199-5p ; hsa-mir-1271-3p ; hsa-mir-148a-3p ; hsa-mir-148b-3p ; hsa-mir-152-3p ; hsa-mir-33b-3p ; hsa-mir-4264 ; hsa-mir-4474-5p ; hsa-mir-4537 ; hsa-mir-4797-3p ; hsa-mir-515-3p ; hsa-mir-519e-3p ; hsa-mir-550a-3-5p ; hsa-mir-550a-5p ; hsa-mir-5708 ; hsa-mir-6751-3p
Nearest miRNA
hsa-let-7f-2/Upstream/8276638; hsa-mir-105-1/Downstream/4521687;
Nearest TSS
ENST00000429181/Upstream/58102; ENST00000371105/Downstream/7246;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/107106, chrX-CpG: 118/Downstream/6335
Upstream sequence
TGGGGCGTTAGATGAGACAGGCAGGGACTAGGGCGGAGGGGACCTGGAGAAGAAGGGAGGCTTTCTGGGGCTAGGTCTCCAAAGTCAGTCCAGGGAGGGG
Downstream sequence
CCAGGAAGATGGACTGGACGGATTCTTGTGAGAGAACGGGAATCATCCAAACTACAGCCAGGAGCACGCCACTGGGGGAAGCAGGCAGGTGAGAAGAGCT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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