Basic Information
VIS ID
TVIS44028006
Fusion event
HTLV-1-NAA10 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
q28
Reference genome
GRCh37/hg19
Start
153196273/153930820 (Hg38)
End
153196273/153930820 (Hg38)
Orient
-
Location type
Exonic
Fragile sites / regions
FRAXE ; FRAXF
Target gene
NAA10
miRNAs that regulate target gene
hsa-mir-16-5p ; hsa-mir-423-3p ; hsa-mir-186-5p ; hsa-let-7b-5p ; hsa-mir-342-5p ; hsa-mir-608 ; hsa-mir-1324 ; hsa-mir-149-5p ; hsa-mir-3064-5p ; hsa-mir-3126-3p ; hsa-mir-3652 ; hsa-mir-4430 ; hsa-mir-4436a ; hsa-mir-4477b ; hsa-mir-4505 ; hsa-mir-4524b-3p ; hsa-mir-4700-3p ; hsa-mir-4794 ; hsa-mir-5000-3p ; hsa-mir-510-5p ; hsa-mir-512-5p ; hsa-mir-5589-5p ; hsa-mir-5787 ; hsa-mir-6504-5p ; hsa-mir-664a-5p ; hsa-mir-6842-3p
Nearest miRNA
hsa-let-7f-2/Upstream/595283; hsa-mir-1184-1/Downstream/50277;
Nearest TSS
ENST00000429181/Upstream/2401; ENST00000438219/Downstream/620;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/2336, chrX-CpG: 112/Downstream/3679
Upstream sequence
GCCGCCCCCGCTCGCCTTGCTTGGCTTCATGCAGGCGCTTACCTCGTCGGCCATCTGAGTGAGGTCCCGCTTCATGGCATAGGCGTCCTCCCCATCTGCA
Downstream sequence
TAGTATTTGGGCTCCACTTCACTGATCCTGGGGGCAGAGGGTTAGAGAGCAAGGAGGAAGACCTGTATCCCGGGGACACCCTCCTCCACTCCTGGTATCG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate