Basic Information
VIS ID
TVIS44028013
Fusion event
HTLV-1-CDKL5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
p22.13
Reference genome
GRCh37/hg19
Start
18597300/18579180 (Hg38)
End
18597300/18579180 (Hg38)
Orient
+
Location type
Intronic
Target gene
CDKL5
miRNAs that regulate target gene
hsa-mir-222-3p
Nearest miRNA
hsa-mir-3690-1/Upstream/1153226; hsa-let-7f-2/Downstream/1437908;
Nearest TSS
ENST00000429181/Upstream/72083; ENST00000623610/Downstream/8506;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/152874, chrX-CpG: 55/Downstream/95852
Upstream sequence
gatccacatgttacactttgagaactgctgtcctagatggttgcttacaaacaataagctgtgattgtaccacgggccttgtactttacagtgagaaagg
Downstream sequence
agaatggttaatctggaaattcagtagagaccggctaagtggaatttctacATAATAAAAAATTTTGCATGAATTTTAGTTATAATGGTCTCTGACTCCA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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