Proximate region of VIS (GRCh38)VISEnhancerEnhancer/PromoterPromoterGene451517814487317745112602449739344497629345005774450073194499720144998400450010014500120045001401450016004500180145002000450112764501142545012479
Basic Information
VIS ID
TVIS44028045
Fusion event
HTLV-1-KDM6A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
p11.3
Reference genome
GRCh37/hg19
Start
44871724/45012479 (Hg38)
End
44871724/45012479 (Hg38)
Orient
+
Location type
Intronic
Target gene
KDM6A
miRNAs that regulate target gene
hsa-mir-218-5p ; hsa-mir-6509-5p ; hsa-mir-6858-5p ; hsa-mir-4689 ; hsa-mir-1224-5p ; hsa-mir-3915 ; hsa-mir-526b-5p ; hsa-mir-3605-5p ; hsa-mir-3679-5p ; hsa-mir-1185-5p ; hsa-mir-6719-3p ; hsa-mir-4526 ; hsa-mir-3660 ; hsa-mir-6730-3p
Nearest miRNA
hsa-mir-1587/Upstream/5174866; hsa-let-7f-2/Downstream/733678;
Nearest TSS
ENST00000429181/Upstream/138764; ENST00000451692/Downstream/46803;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/138372, chrX-CpG: 20/Downstream/145253
Nearest cancer related gene
KDM6A(TSG, No orient, 0)
Upstream sequence
tttagtagagacggagttttaccatgttggccaggctggtgtcgaactcctgacctcaagtgatccgcccacctcagcctcccaaaatgctaggattaca
Downstream sequence
ggtgtgagccaccacacctggTGACATTTTTTATTTTTAGTGTATCTGACCTTTTCAGAGTCCCTTCTGTGCTCCAGAATTTTAAGCTCACGGGTGAGTT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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