Basic Information
VIS ID
TVIS44028073
Fusion event
HTLV-1-NHSL2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
71169593/71949743 (Hg38)
End
71169593/71949743 (Hg38)
Orient
+
Location type
Intronic
Target gene
NHSL2
miRNAs that regulate target gene
hsa-mir-577 ; hsa-mir-183-5p ; hsa-mir-4777-5p ; hsa-mir-6502-5p ; hsa-mir-1301-5p ; hsa-mir-5585-5p ; hsa-mir-548ax ; hsa-mir-548ao-5p ; hsa-mir-4699-5p ; hsa-mir-517-5p ; hsa-mir-1245b-3p ; hsa-mir-654-3p ; hsa-mir-520e ; hsa-mir-520d-3p ; hsa-mir-520c-3p ; hsa-mir-520b ; hsa-mir-520a-3p ; hsa-mir-373-3p ; hsa-mir-372-3p ; hsa-mir-302e ; hsa-mir-302d-3p ; hsa-mir-302c-3p ; hsa-mir-302b-3p ; hsa-mir-302a-3p ; hsa-mir-519c-3p ; hsa-mir-519b-3p ; hsa-mir-519a-3p ; hsa-mir-562 ; hsa-mir-574-5p ; hsa-mir-6867-5p ; hsa-mir-3115 ; hsa-mir-5010-3p ; hsa-mir-2113 ; hsa-mir-147a ; hsa-mir-6818-5p ; hsa-mir-6832-3p ; hsa-mir-6779-3p ; hsa-mir-4687-5p ; hsa-mir-129-2-3p ; hsa-mir-129-1-3p
Nearest miRNA
hsa-let-7f-2/Upstream/1926820; hsa-mir-105-1/Downstream/2268634;
Nearest TSS
ENST00000429181/Upstream/38925; ENST00000631833/Downstream/77738;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/37773, chrX-CpG: 50/Downstream/68735
Upstream sequence
GCAATTGCTGCCACACTCTGCATCAAACCCCCAACTCCCCGTCTGACTTTGCCTATCCTCCACCTCCTCTCCTACTCTGGCAGCTTCAGTAAAGCAGGAA
Downstream sequence
TCACTCAGCTCTGTGTGTGGGAAAGCACAGAGCCCACAGCGCAAACATACAGGCTCATCGGAAACTCGAAATCCCCCCTCTGCCTTCCACATACCAAGCC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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