Basic Information
VIS ID
TVIS44028077
Fusion event
HTLV-1-ATRX integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
76920016/77664527 (Hg38)
End
76920016/77664527 (Hg38)
Orient
+
Location type
Intronic
Target gene
ATRX
miRNAs that regulate target gene
hsa-mir-30a-5p ; hsa-mir-21-5p ; hsa-mir-342-5p ; hsa-mir-615-3p ; hsa-mir-331-3p ; hsa-mir-17-5p ; hsa-mir-200c-3p ; hsa-mir-200a-3p ; hsa-mir-129-5p ; hsa-mir-6505-5p ; hsa-mir-7850-5p ; hsa-mir-320e
Nearest miRNA
hsa-let-7f-2/Upstream/659026; hsa-mir-105-1/Downstream/1236667;
Nearest TSS
ENST00000429181/Upstream/12251; ENST00000475465/Downstream/17614;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/216346, chrX-CpG: 54/Downstream/120990
Upstream sequence
tttagtagagacagggtttcaccatgttggtcaggctggtctcaaactcttaacctcaagtgatccacctgctttggcctcccaaagtcctgagattata
Downstream sequence
ggcgtgagccaccacgccgggccATATTAAGATATTTCTTGGTCAGATATTCTTCAAAGACTGAATTAGTCAAGGAATCAAATTATGACATTATAAACTT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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