Basic Information
VIS ID
TVIS44028141
Fusion event
HTLV-1-LAT2 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr7
Cytoband
q11.23
Reference genome
NCBI36/hg18
Start
73270672/74218406 (Hg38)
End
73270672/74218406 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA7J
Target gene
LAT2
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-4648 ; hsa-mir-4697-3p ; hsa-mir-365b-5p ; hsa-mir-365a-5p ; hsa-mir-8052 ; hsa-mir-3199 ; hsa-mir-150-5p ; hsa-mir-6814-5p ; hsa-mir-3691-3p ; hsa-mir-194-3p ; hsa-mir-5693 ; hsa-mir-6857-5p ; hsa-mir-3682-5p ; hsa-mir-4450 ; hsa-mir-8089 ; hsa-mir-4700-5p ; hsa-mir-4667-5p ; hsa-mir-660-3p ; hsa-mir-5193 ; hsa-mir-6756-3p ; hsa-mir-3127-3p ; hsa-mir-1273e ; hsa-mir-1273f ; hsa-mir-3689d ; hsa-mir-377-5p ; hsa-mir-4252 ; hsa-mir-4459 ; hsa-mir-4537 ; hsa-mir-455-3p ; hsa-mir-566 ; hsa-mir-6086 ; hsa-mir-6134 ; hsa-mir-6499-3p ; hsa-mir-6516-5p ; hsa-mir-652-3p ; hsa-mir-665 ; hsa-mir-6789-3p ; hsa-mir-6840-3p ; hsa-mir-6851-5p ; hsa-mir-6880-5p ; hsa-mir-7847-3p
Nearest miRNA
hsa-mir-1183/Upstream/27112; hsa-mir-10399/Downstream/377562;
Nearest TSS
ENST00000635602/Upstream/8383; ENST00000490586/Downstream/2052;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/43395, chr7-CpG: 82/Downstream/35657
Nearest cancer related gene
LAT2(TSG, No orient, 0)
Upstream sequence
GGGTATCTCTCCTAAATCAGGTCACCCTGAGCCCCAGTCTTCAAGGAGCTTGGAAGGCTGGGCCAGGTACCCATTCTGGTTCAGAGGAGGAGCCCCCAAA
Downstream sequence
CCTGCTTTAATAATGAGCTAATCCACTCCATTATCTGTAATGGCAGCTTCCATTTTCAAGAGcacctcatggtccaagatggcagctggggtgccggccc
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate