Basic Information
VIS ID
TVIS44028146
Fusion event
HTLV-1-CAMK2A integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr5
Cytoband
q32
Reference genome
NCBI36/hg18
Start
149639505/150279749 (Hg38)
End
149639505/150279749 (Hg38)
Orient
-
Location type
Intronic
Target gene
CAMK2A
miRNAs that regulate target gene
hsa-mir-4665-5p ; hsa-mir-1275 ; hsa-mir-4472 ; hsa-mir-4447 ; hsa-mir-92a-2-5p ; hsa-mir-5010-5p ; hsa-mir-7111-5p ; hsa-mir-4525 ; hsa-mir-6870-5p ; hsa-mir-5698 ; hsa-mir-4723-5p ; hsa-mir-625-5p ; hsa-mir-486-3p ; hsa-mir-6825-5p ; hsa-mir-6721-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-4736 ; hsa-mir-505-5p ; hsa-mir-3665 ; hsa-mir-8082 ; hsa-mir-4534 ; hsa-mir-6743-5p ; hsa-mir-4688 ; hsa-mir-1251-3p ; hsa-mir-520f-3p ; hsa-mir-302c-3p
Nearest miRNA
hsa-mir-10397/Upstream/546859; hsa-mir-103a-1/Downstream/1242338;
Nearest TSS
ENST00000502646/Upstream/14352; ENST00000643812/Downstream/9880;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/89367, chr5-CpG: 48/Downstream/17666
Upstream sequence
GGAGCCACAGCGAGGTAAAGAAGGGGCTGCTCACCAGGGTTGAGTAGCCTGCCCCTGAGGGTGGACGAGCAGGAGTGTGGGCAGGCAGGGAGGCCCCCCT
Downstream sequence
CCGGCACTTCGGCAGACAGACGGAGAGGGCACAGTGACAGTGGGTCCGGCGCATGGCTGAGAATGTGGGAACGTGCTAATGGGCTGTGAAAAGCAAGATT
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
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