Basic Information
VIS ID
TVIS44028151
Fusion event
HTLV-1-XPO1 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr2
Cytoband
p15
Reference genome
NCBI36/hg18
Start
61560275/61479636 (Hg38)
End
61560275/61479636 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
XPO1
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-155-5p ; hsa-mir-192-5p ; hsa-mir-30a-5p ; hsa-mir-16-5p ; hsa-mir-1236-3p ; hsa-mir-125a-5p ; hsa-mir-23b-3p ; hsa-mir-92a-3p ; hsa-mir-17-3p ; hsa-mir-30c-5p ; hsa-mir-30d-5p ; hsa-mir-30b-5p ; hsa-mir-30e-5p ; hsa-mir-382-5p ; hsa-mir-485-5p ; hsa-mir-4495 ; hsa-mir-4538 ; hsa-mir-4453 ; hsa-mir-224-5p
Nearest miRNA
hsa-mir-1301/Upstream/1092191; hsa-mir-10b/Downstream/726190;
Nearest TSS
ENST00000437798/Upstream/8181; ENST00000605437/Downstream/3737;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/7971, chr2-CpG: 64/Downstream/58635
Upstream sequence
agtatctcatgcatcccatcccctaagtatatacacctactatgtattcacacaaattttgttctctttgtgatagagtcttgttctgtagccccagcac
Downstream sequence
attatctcaacctcttcctccaagatgcaagcaattctcctgcctcagcctccccagcagctgggattacaggcaccaccacatctggctcattttttgt
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate