Basic Information
VIS ID
TVIS44028166
Fusion event
HTLV-1-PLEC integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr8
Cytoband
q24.3
Reference genome
NCBI36/hg18
Start
145089519/143943363 (Hg38)
End
145089519/143943363 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA8D
Target gene
PLEC
miRNAs that regulate target gene
hsa-mir-7-5p ; hsa-mir-124-3p ; hsa-mir-16-5p ; hsa-mir-769-3p ; hsa-mir-615-3p ; hsa-mir-6796-5p ; hsa-mir-7109-5p ; hsa-mir-3978 ; hsa-mir-6790-5p ; hsa-mir-6742-5p ; hsa-mir-4658 ; hsa-mir-4472 ; hsa-mir-4447 ; hsa-mir-3151-5p ; hsa-mir-491-5p ; hsa-mir-4792 ; hsa-mir-6842-5p ; hsa-mir-7110-5p ; hsa-mir-6752-5p ; hsa-mir-6885-5p ; hsa-mir-328-5p ; hsa-mir-6887-5p ; hsa-mir-6795-5p ; hsa-mir-3659 ; hsa-mir-4487 ; hsa-mir-574-5p ; hsa-mir-558 ; hsa-mir-3160-3p ; hsa-mir-875-3p ; hsa-mir-6835-3p ; hsa-mir-1266-5p ; hsa-mir-127-5p ; hsa-mir-1293 ; hsa-mir-1827 ; hsa-mir-1909-3p ; hsa-mir-3174 ; hsa-mir-323a-5p ; hsa-mir-3612 ; hsa-mir-363-5p ; hsa-mir-3664-3p ; hsa-mir-4257 ; hsa-mir-4433a-3p ; hsa-mir-4433b-3p ; hsa-mir-4443 ; hsa-mir-4459 ; hsa-mir-4483 ; hsa-mir-4518 ; hsa-mir-4651 ; hsa-mir-4768-3p ; hsa-mir-518a-5p ; hsa-mir-527 ; hsa-mir-608 ; hsa-mir-650 ; hsa-mir-6722-3p ; hsa-mir-6745 ; hsa-mir-6782-5p ; hsa-mir-6804-5p ; hsa-mir-6808-5p ; hsa-mir-6847-5p ; hsa-mir-6854-5p ; hsa-mir-6880-5p ; hsa-mir-6893-5p ; hsa-mir-7847-3p ; hsa-mir-940
Nearest miRNA
hsa-mir-1204/Upstream/105547; hsa-mir-10400/Downstream/1828;
Nearest TSS
ENST00000518652/Upstream/839; ENST00000530898/Downstream/595;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/615, chr8-CpG: 54/Downstream/337
Upstream sequence
CCTGTGCTGGGCACGGTTGCCACCTGGGACCACAGCCCAGGAGCTGGTGACTTTGAGCAGGGAGGGCAGGGCACAGCCTGGCTGCCCCCGCCCCCTGTGC
Downstream sequence
GGCCCGAGGGCATGAGGGCACCTGCCTCACCTGCGTGTGGCTCCACCCCCTGCTGTGTGTGCAGGGAGCCACCTCCACCTCAGTGCTGGCCGGACAGGCA
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate