Basic Information
VIS ID
TVIS44028169
Fusion event
HTLV-1-AHNAK integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr11
Cytoband
q12.3
Reference genome
NCBI36/hg18
Start
62028398/62504350 (Hg38)
End
62028398/62504350 (Hg38)
Orient
+
Location type
Intronic
Target gene
AHNAK
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-34a-5p ; hsa-mir-1303 ; hsa-mir-421 ; hsa-mir-324-5p
Nearest miRNA
hsa-mir-129-2/Upstream/626072; hsa-let-7a-2/Downstream/62661;
Nearest TSS
ENST00000527297/Upstream/77626; ENST00000544108/Downstream/13007;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/59626, chr11-CpG: 99/Downstream/41460
Nearest cancer related gene
AHNAK(TSG, No orient, 0)
Upstream sequence
ACGCAATTTTTGGAAAAACATGATGTTTAAATAGCGTGAAGGACAAAAAGCCTAGCATCCCTGCCAGGCCCCCCAGCAAATTTACCCAGAGCTTATCCCA
Downstream sequence
CCTGGGGCTCCTCCCTCCTGCAGCTAAATTCCTAGAATTTAttttctaggaatttttctaggaatttAGACAATCCGCACTGGCTGCCTCCACTCTCTCA
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
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