Basic Information
VIS ID
TVIS44028213
Fusion event
HTLV-1-ALKBH4 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr7
Cytoband
q22.1
Reference genome
NCBI36/hg18
Start
101885634/102458182 (Hg38)
End
101885634/102458182 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA7F
Target gene
ALKBH4
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-193b-3p ; hsa-mir-92a-3p ; hsa-mir-335-3p ; hsa-mir-1305 ; hsa-mir-153-5p ; hsa-mir-548o-3p ; hsa-mir-1323 ; hsa-mir-212-3p ; hsa-mir-132-3p ; hsa-mir-607 ; hsa-mir-5696 ; hsa-mir-4729 ; hsa-mir-3662 ; hsa-mir-6883-3p ; hsa-mir-3671 ; hsa-mir-676-5p ; hsa-mir-1266-3p ; hsa-mir-4762-5p ; hsa-mir-10b-5p ; hsa-mir-10a-5p ; hsa-mir-6732-3p
Nearest miRNA
hsa-mir-10525/Upstream/52327; hsa-mir-10399/Downstream/7560;
Nearest TSS
ENST00000635602/Upstream/21883; ENST00000626402/Downstream/6675;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/245, chr7-CpG: 83/Downstream/6494
Upstream sequence
AAAGCCCCCTGGCTTCATGGAGGTGAAGCAGGAGGAGGCAGACTCAAGGAGACAGAAGTGACAGCAAATggccgggcatggtggtgcatgcctgtaatcc
Downstream sequence
cagcgctttggaaggctgaggcggagggagctcttgaggccaggagtttgagaccagtctgggcaacaaagtgagacctcctctctacaagaaatttaaa
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate