VISDB - VIS Detail

Basic Information

VIS ID

TVIS44028230

Fusion event

HTLV-1-FURIN integration

Validated

Detection method

HTS

Data source

Curated

Sample type

Nontumor

Disease

Not given

Quality evaluation

Normal

Reported year

2019

PubMed ID

30307560

Virus Sequence

Virus name

HTLV-1

Subtype

HTLV-1c

Reference genome

KF242506

Host Sequence

Chromosome

chr15

Cytoband

q26.1

Reference genome

NCBI36/hg18

Start

89220164/90875930 (Hg38)

End

89220164/90875930 (Hg38)

Orient

Location type

Intronic

Target gene

FURIN

miRNAs that regulate target gene

hsa-mir-24-3p ; hsa-mir-103a-3p ; hsa-mir-16-5p ; hsa-mir-615-3p ; hsa-mir-484 ; hsa-mir-6778-5p ; hsa-mir-1233-5p ; hsa-mir-6766-5p ; hsa-mir-6756-5p ; hsa-mir-6508-3p ; hsa-mir-6739-5p ; hsa-mir-6733-5p ; hsa-mir-3153 ; hsa-mir-4505 ; hsa-mir-5787 ; hsa-mir-6089 ; hsa-mir-4286 ; hsa-mir-6783-5p ; hsa-mir-6856-5p ; hsa-mir-6758-5p ; hsa-mir-140-3p ; hsa-mir-6838-5p ; hsa-mir-497-5p ; hsa-mir-424-5p ; hsa-mir-195-5p ; hsa-mir-15a-5p ; hsa-mir-15b-5p ; hsa-mir-107 ; hsa-mir-1273h-5p ; hsa-mir-148a-3p ; hsa-mir-148b-3p ; hsa-mir-149-3p ; hsa-mir-152-3p ; hsa-mir-302c-3p ; hsa-mir-30b-3p ; hsa-mir-328-5p ; hsa-mir-3689a-3p ; hsa-mir-3689b-3p ; hsa-mir-3689c ; hsa-mir-4253 ; hsa-mir-4640-5p ; hsa-mir-4697-3p ; hsa-mir-4726-5p ; hsa-mir-4728-5p ; hsa-mir-4738-5p ; hsa-mir-520f-3p ; hsa-mir-6076 ; hsa-mir-6779-5p ; hsa-mir-6780a-5p ; hsa-mir-6785-5p ; hsa-mir-6797-3p ; hsa-mir-6799-5p ; hsa-mir-6862-5p ; hsa-mir-6883-5p ; hsa-mir-6885-5p ; hsa-mir-7106-5p ; hsa-mir-1285-3p ; hsa-mir-3187-5p ; hsa-mir-331-3p ; hsa-mir-4292 ; hsa-mir-4779 ; hsa-mir-5189-5p ; hsa-mir-612 ; hsa-mir-6721-5p ; hsa-mir-6731-5p ; hsa-mir-6791-5p ; hsa-mir-6805-5p ; hsa-mir-6860 ; hsa-mir-8085 ; hsa-mir-939-3p

Nearest miRNA

hsa-mir-10393/Upstream/869089; hsa-mir-1302-10/Downstream/2028469;

Nearest TSS

ENST00000557528/Upstream/242; ENST00000560018/Downstream/2264;

Nearest CpG islands

None/Target, chr15-CpG: 55/Upstream/3650, chr15-CpG: 19/Downstream/5416

Upstream sequence

ACCAACACGTGGGCTGTGCGCATCCCTGGAGGCCCAGCGGTGGCCAACAGTGTGGCACGGAAGCATGGGTTCCTCAACCTGGGCCAGGTAGGTGTTCCCC

Downstream sequence

CACAGGACACTGCCAGGGGGTGGGACCAGAGAAGACAGGGATTCTGGGAGCAGGAGCTGTTGGCCTTGTTTGCTCAGGGGCATCTGGGTAGCCGGCATGT

Reference

Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.