Basic Information
VIS ID
TVIS44028277
Fusion event
HTLV-1-ARHGAP35 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr19
Cytoband
q13.32
Reference genome
NCBI36/hg18
Start
52193345/46998248 (Hg38)
End
52193345/46998248 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
ARHGAP35
miRNAs that regulate target gene
hsa-mir-296-3p ; hsa-mir-181b-5p ; hsa-mir-17-5p ; hsa-mir-20a-5p ; hsa-mir-93-5p ; hsa-mir-106b-5p ; hsa-mir-20b-5p ; hsa-mir-519d-3p ; hsa-mir-574-5p ; hsa-mir-5010-3p ; hsa-mir-2113 ; hsa-mir-147a ; hsa-mir-3611 ; hsa-mir-6818-5p ; hsa-mir-6867-5p ; hsa-mir-4670-3p ; hsa-mir-6749-3p ; hsa-mir-6763-3p ; hsa-mir-660-3p ; hsa-mir-5193 ; hsa-mir-5587-3p ; hsa-mir-4707-5p ; hsa-mir-5196-3p ; hsa-mir-6501-3p ; hsa-mir-6768-3p ; hsa-mir-1827 ; hsa-mir-3612 ; hsa-mir-4443 ; hsa-mir-4524a-3p ; hsa-mir-4722-5p ; hsa-mir-4768-3p ; hsa-mir-5091 ; hsa-mir-548aa ; hsa-mir-548ap-3p ; hsa-mir-548t-3p ; hsa-mir-650 ; hsa-mir-6786-3p ; hsa-mir-6808-5p ; hsa-mir-6880-5p ; hsa-mir-6893-5p ; hsa-mir-7847-3p ; hsa-mir-940 ; hsa-mir-198 ; hsa-mir-210-3p ; hsa-mir-6774-3p ; hsa-mir-4330
Nearest miRNA
hsa-mir-10395/Upstream/288894; hsa-let-7e/Downstream/228694;
Nearest TSS
ENST00000633603/Upstream/8664; ENST00000598548/Downstream/837;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/136703, chr19-CpG: 40/Downstream/5801
Upstream sequence
CCGCACCCCTCCCGGATTCATCAGCAGAATGGCACACATATGTCTCCGGCCGAGACGGTCTGGCACCATCATCTATCCCAAAGGAGCCCGAGCCCCCGGG
Downstream sequence
CCCATTAGCAATCATCTGCGCTTTAACAGGCCTCTCTTCACCACCCCCACAGCCGCCAGCTGTGAGGTCGCTGCCATCTCCTTCGTGAGACCCTCCTGTG
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate