Basic Information
VIS ID
TVIS44028292
Fusion event
HTLV-1-MAN1A2 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr1
Cytoband
p12
Reference genome
NCBI36/hg18
Start
117713288/117369143 (Hg38)
End
117713288/117369143 (Hg38)
Orient
-
Location type
Intronic
Target gene
MAN1A2
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-142-3p ; hsa-mir-30a-5p ; hsa-mir-130b-3p ; hsa-mir-541-5p ; hsa-mir-3653-3p ; hsa-mir-6869-5p ; hsa-mir-496 ; hsa-mir-8087 ; hsa-mir-7161-5p ; hsa-mir-548u ; hsa-mir-4455 ; hsa-mir-640 ; hsa-mir-6867-5p ; hsa-mir-4286 ; hsa-mir-4262 ; hsa-mir-216b-3p ; hsa-mir-181d-5p ; hsa-mir-181c-5p ; hsa-mir-181b-5p ; hsa-mir-181a-5p ; hsa-mir-190a-3p ; hsa-mir-5011-5p ; hsa-mir-3976 ; hsa-mir-6856-5p ; hsa-mir-6758-5p ; hsa-mir-1277-5p ; hsa-mir-3125 ; hsa-mir-3916 ; hsa-mir-4662a-3p ; hsa-mir-4662a-5p ; hsa-mir-6124 ; hsa-mir-6832-5p ; hsa-mir-6859-5p ; hsa-mir-8081
Nearest miRNA
hsa-mir-101-1/Upstream/274415; hsa-mir-1182/Downstream/28481444;
Nearest TSS
ENST00000473358/Upstream/1200; ENST00000449370/Downstream/51454;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/1320, chr1-CpG: 135/Downstream/236193
Upstream sequence
TTTTTTTGGGGATGTGTGTTGGTGCTGTATATGAAATCAGTTAAGTTAAAAGGTATTGAATCCTAAGTTATTGCACTTTGTGAGGCTTGTAGACAAGATT
Downstream sequence
TATTTTTGTGAAACTTAATTTTGCTCTCTCTTTTAATGTAATAGATGGACTGTGTCAAGCAACTATTGGAATTTGGTTGATTAAGGGGTTCACATTCTTT
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate