Basic Information
VIS ID
TVIS44028316
Fusion event
HTLV-1-ERLIN1 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr10
Cytoband
q24.31
Reference genome
NCBI36/hg18
Start
101926941/100177194 (Hg38)
End
101926941/100177194 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
ERLIN1
miRNAs that regulate target gene
hsa-mir-34a-5p ; hsa-mir-30a-5p ; hsa-mir-615-3p ; hsa-mir-10b-5p ; hsa-mir-10a-5p ; hsa-mir-30c-5p ; hsa-mir-17-5p ; hsa-mir-218-5p ; hsa-mir-30e-5p ; hsa-mir-30d-5p ; hsa-mir-30b-5p
Nearest miRNA
hsa-mir-107/Upstream/1252626; hsa-mir-1307/Downstream/797791;
Nearest TSS
ENST00000439456/Upstream/95317; ENST00000443919/Downstream/8835;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/61812, chr10-CpG: 43/Downstream/8620
Upstream sequence
ctgggtgacagaacaagactccatctcaaaaaagaaaaaaaaTTAATGGACAGGCCATTAATAAATACTTAATGACTAAATCATTTGCTTGATCATTTCC
Downstream sequence
CAAATGAATTATATCTAAATAGTTTCCTATTTAATCTCTGGTTAAAGAATCATCAGTCCCTTCCCTTTTTCAATCATAATCCATTCCAGTGATTTGTAAT
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate