VISDB - VIS Detail

Basic Information

VIS ID

TVIS44028329

Fusion event

HTLV-1-ARHGAP1 integration

Validated

Detection method

HTS

Data source

Curated

Sample type

Nontumor

Disease

Not given

Quality evaluation

Normal

Reported year

2019

PubMed ID

30307560

Virus Sequence

Virus name

HTLV-1

Subtype

HTLV-1c

Reference genome

KF242506

Host Sequence

Chromosome

chr11

Cytoband

p11.2

Reference genome

NCBI36/hg18

Start

46674195/46696069 (Hg38)

End

46674195/46696069 (Hg38)

Orient

Location type

Intronic

Target gene

ARHGAP1

miRNAs that regulate target gene

hsa-mir-130b-3p ; hsa-mir-34a-5p ; hsa-mir-93-5p ; hsa-mir-19b-3p ; hsa-mir-20a-5p ; hsa-mir-106b-5p ; hsa-mir-433-5p ; hsa-mir-519c-3p ; hsa-mir-519b-3p ; hsa-mir-519a-3p ; hsa-mir-553 ; hsa-mir-548t-5p ; hsa-mir-548az-5p ; hsa-mir-106a-5p ; hsa-mir-17-5p ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-526b-3p ; hsa-mir-301b-3p ; hsa-mir-301a-3p ; hsa-mir-130a-3p ; hsa-mir-454-3p ; hsa-mir-4295 ; hsa-mir-3666 ; hsa-mir-19a-3p ; hsa-mir-1273e ; hsa-mir-25-5p ; hsa-mir-658 ; hsa-mir-1827 ; hsa-mir-219b-3p ; hsa-mir-4649-3p ; hsa-mir-4768-3p ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p ; hsa-mir-1912 ; hsa-mir-1295b-5p ; hsa-mir-302f ; hsa-mir-525-5p ; hsa-mir-520a-5p ; hsa-mir-506-3p ; hsa-mir-124-3p ; hsa-mir-198 ; hsa-mir-6770-5p ; hsa-mir-1253 ; hsa-mir-3919 ; hsa-mir-449c-5p ; hsa-mir-34b-5p ; hsa-mir-2682-5p ; hsa-mir-6511a-5p ; hsa-mir-1910-3p ; hsa-mir-6856-5p ; hsa-mir-6758-5p ; hsa-mir-3910 ; hsa-mir-3714 ; hsa-mir-424-3p ; hsa-mir-449b-5p ; hsa-mir-449a ; hsa-mir-34c-5p ; hsa-mir-6765-5p ; hsa-mir-4316 ; hsa-mir-3197 ; hsa-mir-6087 ; hsa-mir-6089 ; hsa-mir-4685-5p ; hsa-mir-6837-5p ; hsa-mir-3918 ; hsa-mir-4722-5p ; hsa-mir-3680-3p ; hsa-mir-557 ; hsa-mir-507 ; hsa-mir-450b-5p ; hsa-mir-19b-2-5p ; hsa-mir-19b-1-5p ; hsa-mir-19a-5p ; hsa-mir-4711-5p ; hsa-mir-7112-3p ; hsa-mir-153-5p ; hsa-mir-4328

Nearest miRNA

hsa-mir-129-2/Upstream/244180; hsa-let-7a-2/Downstream/57056;

Nearest TSS

ENST00000527297/Upstream/14553; ENST00000531866/Downstream/30;

Nearest CpG islands

None/Target, chr11-CpG: 30/Upstream/78133, chr11-CpG: 34/Downstream/4360

Upstream sequence

CCCACCTGACTTGGGGAAGTCAGGCATTTCATCCGAGGGCCAGTTCTTCTCATCGATGGAGGCCAGCTTCAGCTGGTTCAGAGCCTCGCTGGTGTCATCC

Downstream sequence

AAGGTCAGATCATCCTGCAGCTCTGAGAGCGGATCCATGGCCAAGCCTGTCCCAGACAGCCTTGCCCTGCAGAACCTTAAGAGAAACCTGGGAGAGAGGA

Reference

Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.