Basic Information
VIS ID
TVIS44028371
Fusion event
HTLV-1-AP3B1 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr5
Cytoband
q14.1
Reference genome
NCBI36/hg18
Start
77494925/78163345 (Hg38)
End
77494925/78163345 (Hg38)
Orient
+
Location type
Intronic
Target gene
AP3B1
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-9-5p ; hsa-mir-214-3p ; hsa-mir-421 ; hsa-mir-221-3p ; hsa-mir-302d-5p ; hsa-mir-302b-5p ; hsa-mir-548t-3p ; hsa-mir-548ap-3p ; hsa-mir-548aa ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac ; hsa-mir-1305 ; hsa-mir-6739-3p ; hsa-mir-375 ; hsa-mir-4677-5p ; hsa-mir-7156-5p ; hsa-mir-4273 ; hsa-mir-19b-2-5p ; hsa-mir-19b-1-5p ; hsa-mir-19a-5p ; hsa-mir-2052 ; hsa-mir-22-5p ; hsa-mir-2116-5p ; hsa-mir-4522 ; hsa-mir-627-3p ; hsa-mir-4431 ; hsa-mir-195-3p ; hsa-mir-16-2-3p ; hsa-mir-3664-5p
Nearest miRNA
hsa-mir-10397/Upstream/5284682; hsa-mir-103a-1/Downstream/4676810;
Nearest TSS
ENST00000502646/Upstream/22175; ENST00000510030/Downstream/131347;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/190382, chr5-CpG: 47/Downstream/130968
Upstream sequence
TTTAAGTGCAAGGTTGAAAGAGATGATGAGAGCTCTCTCTTTGGAGGTTTCAGTTCATTTACCAGCAGCATCTGTGAATCTATGAAAAAAAGGGTCACTT
Downstream sequence
TTTCAGAGACACTAAATCTAAAAACTGGGAGAAAAGGAAGAAAGGGACCAGTAGGCTATTTACAAACATTTTAATTTCAAAATCTATCACAATGGTTGTA
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate