Basic Information
VIS ID
TVIS44028379
Fusion event
HTLV-1-FTO integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr16
Cytoband
q12.2
Reference genome
NCBI36/hg18
Start
52665769/54074356 (Hg38)
End
52665769/54074356 (Hg38)
Orient
+
Location type
Intronic
Target gene
FTO
miRNAs that regulate target gene
hsa-let-7b-5p ; hsa-mir-6513-5p ; hsa-mir-887-5p ; hsa-mir-3913-5p ; hsa-mir-3122 ; hsa-mir-450a-1-3p ; hsa-mir-6779-5p ; hsa-mir-6780a-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-6788-5p ; hsa-mir-30c-2-3p ; hsa-mir-30c-1-3p ; hsa-mir-7977 ; hsa-mir-8085 ; hsa-mir-6731-5p ; hsa-mir-6878-5p ; hsa-mir-4738-5p ; hsa-mir-6134 ; hsa-mir-6807-5p ; hsa-mir-4266 ; hsa-mir-4641 ; hsa-mir-1233-3p ; hsa-mir-1225-3p ; hsa-mir-8060 ; hsa-mir-4768-3p ; hsa-mir-4779 ; hsa-mir-4695-5p
Nearest miRNA
hsa-mir-1225/Upstream/3331979; hsa-mir-11401/Downstream/2171164;
Nearest TSS
ENST00000527434/Upstream/4460; ENST00000637049/Downstream/75334;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/370033, chr16-CpG: 21/Downstream/47685
Upstream sequence
TTCTGGGTTTGCTTTTTTAATTAACATGTTTTAAATTAGCATgtaatctgtcttcattaaagacatgttttgaaaattcagagaagtataaaacagaaag
Downstream sequence
gaaaagtctcctgtaagcctaccaccttgggtaccactaggaatatttgagcctgttgcctcccagtctgtttttaatgcatatatacttgtatatatac
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate