Basic Information
VIS ID
TVIS44028427
Fusion event
HTLV-1-PRKG2 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr4
Cytoband
q21.21
Reference genome
NCBI36/hg18
Start
82277918/81137740 (Hg38)
End
82277918/81137740 (Hg38)
Orient
+
Location type
Intronic
Target gene
PRKG2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-1-3p ; hsa-mir-4659b-3p ; hsa-mir-4659a-3p ; hsa-mir-6875-3p ; hsa-mir-452-3p ; hsa-mir-548l ; hsa-mir-8054 ; hsa-mir-548k ; hsa-mir-548av-5p ; hsa-mir-559 ; hsa-mir-548y ; hsa-mir-548w ; hsa-mir-548o-5p ; hsa-mir-548j-5p ; hsa-mir-548i ; hsa-mir-548h-5p ; hsa-mir-548d-5p ; hsa-mir-548c-5p ; hsa-mir-548bb-5p ; hsa-mir-548b-5p ; hsa-mir-548ay-5p ; hsa-mir-548au-5p ; hsa-mir-548as-5p ; hsa-mir-548ar-5p ; hsa-mir-548aq-5p ; hsa-mir-548ap-5p ; hsa-mir-548am-5p ; hsa-mir-548ak ; hsa-mir-548ae-5p ; hsa-mir-548ad-5p ; hsa-mir-548ab ; hsa-mir-548a-5p
Nearest miRNA
hsa-mir-12113/Upstream/4562114; hsa-mir-1243/Downstream/1615597;
Nearest TSS
ENST00000502981/Upstream/106775; ENST00000505175/Downstream/15992;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/106086, chr4-CpG: 73/Downstream/76994
Upstream sequence
TTTCCCCACTGCCTTGCTTCTGCTCCTGTGGATCTCACTTAGATTGGCCTTTCTCTAACCACAGACTGAACTTCTTAATCTCAGTTTTACCGTAAAAATG
Downstream sequence
TTATCCATTCTTCAGGGCCAACCTCCAAGGCCATCTTTTTAACAAAACATCTCATTATCCCACCTACCAAATATGTCCTCTCCTTTTTCCAAAACCTTAG
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate