Basic Information
VIS ID
TVIS44028450
Fusion event
HTLV-1-CEP89 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr19
Cytoband
q13.11
Reference genome
NCBI36/hg18
Start
38093651/32910905 (Hg38)
End
38093651/32910905 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
CEP89
miRNAs that regulate target gene
hsa-mir-193a-3p ; hsa-mir-6842-3p ; hsa-mir-6807-5p ; hsa-mir-7151-3p ; hsa-mir-5095 ; hsa-mir-4430 ; hsa-mir-3652 ; hsa-mir-3922-3p ; hsa-mir-3176 ; hsa-mir-4433a-3p ; hsa-mir-6504-3p ; hsa-mir-889-5p ; hsa-mir-4433b-3p ; hsa-mir-4700-3p ; hsa-mir-7153-3p ; hsa-mir-6749-3p ; hsa-mir-1260b ; hsa-mir-1260a ; hsa-mir-532-3p ; hsa-mir-4726-3p ; hsa-mir-6764-5p ; hsa-mir-1915-3p ; hsa-mir-6840-3p ; hsa-mir-1224-3p ; hsa-mir-484 ; hsa-mir-3155b ; hsa-mir-3155a ; hsa-mir-6513-3p ; hsa-mir-4714-3p ; hsa-mir-8079 ; hsa-mir-1245a ; hsa-mir-5698 ; hsa-mir-7156-3p ; hsa-mir-143-5p ; hsa-mir-3622b-5p ; hsa-mir-6499-3p ; hsa-mir-1184 ; hsa-mir-1304-3p ; hsa-mir-103b ; hsa-mir-5693 ; hsa-mir-6890-3p ; hsa-mir-7705 ; hsa-mir-6854-5p ; hsa-mir-509-5p ; hsa-mir-509-3-5p ; hsa-mir-4418 ; hsa-mir-656-5p ; hsa-mir-122-5p ; hsa-mir-504-3p ; hsa-mir-3135b ; hsa-mir-6765-3p
Nearest miRNA
hsa-mir-10395/Upstream/12511551; hsa-let-7e/Downstream/2211795;
Nearest TSS
ENST00000633603/Upstream/32484; ENST00000590281/Downstream/49047;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/189731, chr19-CpG: 48/Downstream/60904
Upstream sequence
ggtcagtaacgtacatggagctgtcacctcctgtgataacaatgcctgcttctggacacgtcctgaaggacccgcctgagcctgttttacagttaacttt
Downstream sequence
attttgttataagtagaaggagtacactctaaaataacaataaaaagtagggtaaatacataaaccagtaacacagtcatttactatcattatcaagtat
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate