Basic Information
VIS ID
TVIS44028453
Fusion event
HTLV-1-BRD4 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr19
Cytoband
p13.12
Reference genome
NCBI36/hg18
Start
15284034/15312223 (Hg38)
End
15284034/15312223 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA19B
Target gene
BRD4
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-2110 ; hsa-mir-877-3p ; hsa-mir-455-3p ; hsa-mir-484 ; hsa-mir-320a ; hsa-mir-544a ; hsa-mir-3680-3p ; hsa-mir-557 ; hsa-mir-507 ; hsa-mir-450b-5p ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-623 ; hsa-mir-6731-3p ; hsa-mir-6832-3p ; hsa-mir-3938 ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-3613-3p ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac ; hsa-mir-380-3p ; hsa-mir-411-3p ; hsa-mir-379-3p ; hsa-mir-4495 ; hsa-mir-1228-3p ; hsa-mir-8485 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-1306-5p
Nearest miRNA
hsa-mir-10395/Upstream/132873; hsa-let-7e/Downstream/137325;
Nearest TSS
ENST00000633603/Upstream/31772; ENST00000601005/Downstream/19683;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/73045, chr19-CpG: 154/Downstream/19227
Nearest cancer related gene
BRD4(OG, No orient, 0)
Upstream sequence
AAATGCCCTCACAGGGCTGGGTCAAATGAAATGCCACACAAAGCAAGTGTTCAATAAACACCTACTACTAATAAAAGCAAGCATCggccaggcacagtag
Downstream sequence
cttgtagctcccatttgtaatccctgcagtttgagcggccaagacaggcacattgcttgaactcaggagttcaaggccagcctgggcaatgtggtgagac
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate