Basic Information
VIS ID
TVIS44028459
Fusion event
HTLV-1-ERBB4 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr2
Cytoband
q34
Reference genome
NCBI36/hg18
Start
212760870/212187900 (Hg38)
End
212760870/212187900 (Hg38)
Orient
+
Location type
Intronic
Target gene
ERBB4
miRNAs that regulate target gene
hsa-mir-372-3p ; hsa-mir-19a-3p ; hsa-mir-302d-3p ; hsa-mir-146a-5p ; hsa-mir-145-5p ; hsa-mir-221-3p ; hsa-mir-302b-3p ; hsa-mir-193a-3p ; hsa-mir-146b-5p
Nearest miRNA
hsa-mir-10b/Upstream/4433019; hsa-mir-1244-1/Downstream/238363;
Nearest TSS
ENST00000437798/Upstream/62719; ENST00000434559/Downstream/241347;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/1711088, chr2-CpG: 86/Downstream/349556
Nearest cancer related gene
ERBB4(TSG, No orient, 0)
Upstream sequence
TTTCAGAGACATGAGTGATCTTCAAAGTGAAATATTAGAAGTGATGTTATGAAATACAAGAAATGTGACTGAGAGCTCCTAATCTGATATATGGCAATAT
Downstream sequence
GTTACCACTCATTAAAGCCCAATTTTAATGCGTTGACAGCTAACCTCGAGAAACAAGACATCTAACTTCAATCCTATAATATTATTTGGTGATatatcct
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate