Basic Information
VIS ID
TVIS44028474
Fusion event
HTLV-1-CCAR1 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr10
Cytoband
q21.3
Reference genome
NCBI36/hg18
Start
70175568/68745805 (Hg38)
End
70175568/68745805 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10C
Target gene
CCAR1
miRNAs that regulate target gene
hsa-mir-24-3p ; hsa-mir-186-5p ; hsa-mir-92a-3p ; hsa-mir-1254 ; hsa-mir-29a-5p ; hsa-mir-548av-3p ; hsa-mir-548g-3p ; hsa-mir-8055
Nearest miRNA
hsa-mir-1265/Upstream/1342395; hsa-mir-107/Downstream/3044942;
Nearest TSS
ENST00000439456/Upstream/24550; ENST00000483264/Downstream/9377;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/23964, chr10-CpG: 185/Downstream/81355
Nearest cancer related gene
CCAR1(TSG, No orient, 0)
Upstream sequence
cacctgcctcagcctcccaaagtgctgggattacaggcgtgagccacaacaacgcccggcaactatttttttttttccagtttcttcagatctagacata
Downstream sequence
aagactaatttttaaattttttgtagaaatgtgatctcacaatgttgcccaagctggtcttgaactgactgcaagtgatcgtttgatttttaaagttatg
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate