Basic Information
VIS ID
TVIS44028489
Fusion event
HTLV-1-CISD1 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr10
Cytoband
q21.1
Reference genome
NCBI36/hg18
Start
59704691/58274925 (Hg38)
End
59704691/58274925 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10C
Target gene
CISD1
miRNAs that regulate target gene
hsa-mir-92b-3p ; hsa-mir-128-3p ; hsa-mir-92a-3p ; hsa-mir-4662a-5p ; hsa-mir-379-5p ; hsa-mir-3529-5p ; hsa-mir-3651 ; hsa-mir-6831-5p ; hsa-mir-3927-3p ; hsa-mir-3156-3p ; hsa-mir-1260b ; hsa-mir-1260a ; hsa-mir-188-3p ; hsa-mir-6739-5p ; hsa-mir-6733-5p ; hsa-mir-3153 ; hsa-mir-4668-5p ; hsa-mir-3148 ; hsa-mir-662 ; hsa-mir-141-5p ; hsa-mir-129-5p
Nearest miRNA
hsa-mir-1265/Upstream/970366; hsa-mir-107/Downstream/5098032;
Nearest TSS
ENST00000439456/Upstream/1492; ENST00000440189/Downstream/29628;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/5444, chr10-CpG: 65/Downstream/60046
Upstream sequence
AGTGACCTGTGGGTGCAGTTGGCAAATTACATGAGAAAAAAGAATGCAAGAAGAATGGGATTTAATGACTAGGAGAGATTATTTTCACTTATCATGATGA
Downstream sequence
GTTTCATGTAGAAATTCCTATAGTATTCTCTTTTTAGGTCATGAAACAAATTAACCAATACTAACCAATTGTAGTTCTTTGGATCTCAGGACTGTTTGCA
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate