Basic Information
VIS ID
TVIS44028492
Fusion event
HTLV-1-PTPRN2 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr7
Cytoband
q36.3
Reference genome
NCBI36/hg18
Start
157568399/158082946 (Hg38)
End
157568399/158082946 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA7I
Target gene
PTPRN2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-539-5p ; hsa-mir-7110-3p ; hsa-mir-372-5p ; hsa-mir-371a-5p ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-5680 ; hsa-mir-4311 ; hsa-mir-6809-3p ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-4753-3p ; hsa-mir-6715b-3p ; hsa-mir-676-5p ; hsa-mir-1236-3p ; hsa-mir-6515-3p ; hsa-mir-1228-3p ; hsa-mir-342-3p
Nearest miRNA
hsa-mir-10399/Upstream/508524; hsa-mir-5707/Downstream/449772;
Nearest TSS
ENST00000635602/Upstream/55573; ENST00000448698/Downstream/122331;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/172147, chr7-CpG: 44/Downstream/2346
Upstream sequence
AGCCGCCTCCAGGGATGACCATGGAGCAGGAGCTGGTGTCTTCTCGAGCCCAGGCCCCAGGCCTGTCTACGGTGCCTCGGCTGGGCCCTCTGCTGGTCCC
Downstream sequence
CACTATGGGCCCTCAGAAAGGAGGAGGCCACTCCCTCCCTGGACTGCAGCTCTCCTGCCAACGATGTTCCACTCGCTCATGAGTGCTGAGTTCTACCCCC
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate