Basic Information
VIS ID
TVIS44028550
Fusion event
HTLV-1-HDAC5 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr17
Cytoband
q21.31
Reference genome
NCBI36/hg18
Start
39520727/44087833 (Hg38)
End
39520727/44087833 (Hg38)
Orient
-
Location type
Intronic
Target gene
HDAC5
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-let-7a-5p ; hsa-mir-6763-5p ; hsa-mir-3150a-3p ; hsa-mir-4536-5p ; hsa-mir-6825-5p ; hsa-mir-939-5p ; hsa-mir-1343-5p ; hsa-mir-7106-5p ; hsa-mir-3175 ; hsa-mir-765 ; hsa-mir-766-5p ; hsa-mir-4533 ; hsa-mir-1252-5p ; hsa-mir-8089 ; hsa-mir-4700-5p ; hsa-mir-4667-5p ; hsa-mir-4476 ; hsa-mir-6876-5p ; hsa-mir-125a-5p ; hsa-mir-675-5p ; hsa-mir-1184 ; hsa-mir-1205 ; hsa-mir-1224-5p ; hsa-mir-1273f ; hsa-mir-17-3p ; hsa-mir-2467-3p ; hsa-mir-3154 ; hsa-mir-3158-5p ; hsa-mir-3179 ; hsa-mir-3678-3p ; hsa-mir-4527 ; hsa-mir-4710 ; hsa-mir-4751 ; hsa-mir-4756-3p ; hsa-mir-4792 ; hsa-mir-5004-5p ; hsa-mir-6503-5p ; hsa-mir-6783-5p ; hsa-mir-7855-5p
Nearest miRNA
hsa-mir-1180/Upstream/642948; hsa-mir-10226/Downstream/119938;
Nearest TSS
ENST00000595228/Upstream/1078; ENST00000585899/Downstream/4350;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/16700, chr17-CpG: 77/Downstream/35320
Upstream sequence
GGGGAGCAGCTGTGCAGCCTAAAACCCAGAACAGTCTATCCTTCCCTCCCTCCCTTCTTCCAGGTAGAGCTTCTATGTGAATTAGAAAAAGGTGAGGTAG
Downstream sequence
CTCCTCTGAGAGGACtttttttttttttgagacagagtctccctctgtcgcccagcctggcatgcagtggcacgatctcggctcactgcaacctccgcct
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate