Basic Information
VIS ID
TVIS44028601
Fusion event
HTLV-1-ARHGAP18 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr6
Cytoband
q22.33
Reference genome
NCBI36/hg18
Start
130052048/129689210 (Hg38)
End
130052048/129689210 (Hg38)
Orient
-
Location type
Intronic
Target gene
ARHGAP18
miRNAs that regulate target gene
hsa-mir-6818-3p ; hsa-mir-593-3p ; hsa-mir-6895-3p ; hsa-mir-4725-5p ; hsa-mir-4696 ; hsa-mir-570-3p ; hsa-mir-5699-3p ; hsa-mir-520f-5p ; hsa-mir-4421 ; hsa-mir-6501-3p ; hsa-mir-339-5p ; hsa-mir-451b ; hsa-mir-10b-5p ; hsa-mir-3667-5p ; hsa-mir-10a-5p ; hsa-mir-4282 ; hsa-mir-6759-5p ; hsa-mir-6796-5p ; hsa-mir-4322 ; hsa-mir-4296 ; hsa-mir-4265 ; hsa-mir-4439 ; hsa-mir-3136-5p ; hsa-mir-4769-5p ; hsa-mir-4654 ; hsa-mir-6778-5p ; hsa-mir-1233-5p ; hsa-mir-4648 ; hsa-mir-3118 ; hsa-mir-134-5p ; hsa-mir-5196-5p ; hsa-mir-4747-5p ; hsa-mir-6857-3p ; hsa-mir-6855-3p ; hsa-mir-4513 ; hsa-mir-15b-3p ; hsa-mir-581 ; hsa-mir-5187-3p ; hsa-mir-2681-3p ; hsa-mir-6848-5p ; hsa-mir-6846-5p ; hsa-mir-4697-5p ; hsa-mir-4488 ; hsa-mir-1237-5p ; hsa-mir-486-3p
Nearest miRNA
hsa-mir-10398/Upstream/3204497; hsa-mir-1202/Downstream/2102962;
Nearest TSS
ENST00000381078/Upstream/90249; ENST00000526087/Downstream/21015;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/759036, chr6-CpG: 208/Downstream/329831
Upstream sequence
ATAAATGGGTGCTGCCACTAATGATCATCTCTGAGGCCTTGTCAGGCATTTGGGAACAAACTTACCAGTCTCCAGCCTGAAAGACACCAAGGAGAAACCT
Downstream sequence
GACAGCTGAGAAGCTCTGATTTCCCTCTCACATGAGGATAAGAGAAACCAGCATGTATTATTTTTTTGGTTGCTTGGATGGttttgttttttgtcttttt
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate