Basic Information
VIS ID
TVIS44028610
Fusion event
HTLV-1-AKAP6 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr14
Cytoband
q12
Reference genome
NCBI36/hg18
Start
32167928/32628971 (Hg38)
End
32167928/32628971 (Hg38)
Orient
-
Location type
Intronic
Target gene
AKAP6
miRNAs that regulate target gene
hsa-mir-1257 ; hsa-mir-4687-3p ; hsa-mir-7974 ; hsa-mir-583 ; hsa-mir-1276 ; hsa-mir-4311 ; hsa-mir-1303 ; hsa-mir-5096 ; hsa-mir-3187-3p ; hsa-mir-4435 ; hsa-mir-588 ; hsa-mir-4701-5p ; hsa-mir-548s ; hsa-mir-7641 ; hsa-mir-197-3p ; hsa-mir-411-5p ; hsa-mir-6832-5p ; hsa-mir-193b-5p ; hsa-mir-4755-3p ; hsa-mir-4695-3p ; hsa-mir-4716-5p ; hsa-mir-4781-3p ; hsa-mir-4478 ; hsa-mir-4419b ; hsa-mir-3929 ; hsa-mir-483-5p
Nearest miRNA
hsa-mir-208a/Upstream/1614229; hsa-mir-1185-1/Downstream/4323338;
Nearest TSS
ENST00000550708/Upstream/11993; ENST00000557396/Downstream/64430;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/425262, chr14-CpG: 168/Downstream/303917
Upstream sequence
ACTTTGTTAAAATATTTAAGTTAAGCCAAATAAAAATGAAAGTTAATGCCAGAACTTTACCATTCGTGATTTATAAATAAGCTGTTTTCTAAATAAAAAT
Downstream sequence
AACCACCCACCTGCAGTCAGATCTCTTAGAGAAATGGGAGGGATGTGCCGTTTGAGGAGGGAATCTTCTATTACTACTCCTCCAGGAACAAAAGAAAGAT
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate