Basic Information
VIS ID
TVIS44028622
Fusion event
HTLV-1-IL17RA integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr22
Cytoband
q11.1
Reference genome
NCBI36/hg18
Start
15972427/17111537 (Hg38)
End
15972427/17111537 (Hg38)
Orient
+
Location type
Intronic
Target gene
IL17RA
miRNAs that regulate target gene
hsa-mir-375 ; hsa-mir-92a-3p ; hsa-mir-3978 ; hsa-mir-6807-5p ; hsa-mir-7160-5p ; hsa-mir-7854-3p ; hsa-mir-6134 ; hsa-mir-6823-3p ; hsa-mir-2114-3p ; hsa-mir-7162-3p ; hsa-mir-135b-5p ; hsa-mir-135a-5p ; hsa-mir-4662b ; hsa-mir-4647 ; hsa-mir-4426 ; hsa-mir-498 ; hsa-mir-5001-3p ; hsa-mir-4279 ; hsa-mir-4772-3p ; hsa-mir-3653-5p ; hsa-mir-10b-3p ; hsa-mir-5571-5p
Nearest miRNA
hsa-let-7a-3/Downstream/652643;
Nearest TSS
ENST00000624155/Upstream/26480; ENST00000428078/Downstream/9716;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/2140, chr22-CpG: 222/Downstream/8136
Upstream sequence
CCTTGTGTGGGGAAGGGGTGCTGCTGTGACTTCAGGGTCTGAGGTCCAAAGACAGCATTTGAAAAGAGGCTCTGAAGCCAGTGTTTGAAGAATTTGTTCC
Downstream sequence
TGAAGTACCTCCTGGGGGTAGGCTAGAGGCTTCTGGCTTCAGGGTCCTGAAGAACACATTGAGGTGCCGTCTGACACTGGAATAGGGTGCCCTTCATTCC
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
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