Basic Information
VIS ID
TVIS44028626
Fusion event
HTLV-1-LRP12 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr8
Cytoband
q22.3
Reference genome
NCBI36/hg18
Start
105646495/104565091 (Hg38)
End
105646495/104565091 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA8A
Target gene
LRP12
miRNAs that regulate target gene
hsa-mir-615-3p ; hsa-mir-5011-5p ; hsa-mir-5093 ; hsa-mir-3688-3p ; hsa-mir-4473 ; hsa-mir-633 ; hsa-mir-636 ; hsa-mir-512-3p ; hsa-mir-548p ; hsa-mir-5692a ; hsa-mir-4796-3p ; hsa-mir-548ah-5p ; hsa-mir-3609 ; hsa-mir-20b-5p ; hsa-mir-20a-5p ; hsa-mir-106a-5p ; hsa-mir-106b-5p ; hsa-mir-519d-3p ; hsa-mir-526b-3p ; hsa-mir-93-5p ; hsa-mir-17-5p ; hsa-mir-520f-3p ; hsa-mir-302c-3p
Nearest miRNA
hsa-mir-12123/Upstream/80626; hsa-mir-10400/Downstream/8078402;
Nearest TSS
ENST00000518652/Upstream/67486; ENST00000521923/Downstream/23904;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/97979, chr8-CpG: 115/Downstream/23134
Upstream sequence
ACTGAAGAATCTTTAAATTATAGAATAAAAAGATAAGGATATTAAAACCTAAGAGACAAAAAAAAGCTAGGTACTTCTATTAAGTGTAATATAATATTCA
Downstream sequence
CTTAATAGTTCTAAATGGATGAAACCTTCAGGATAAAATGGATTTAAAacacatatacaagtgtagacatatatatgtgcacacatatccataataaata
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate