Basic Information
VIS ID
TVIS44028650
Fusion event
HTLV-1-TMEM63C integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr14
Cytoband
q24.3
Reference genome
NCBI36/hg18
Start
76726470/77190374 (Hg38)
End
76726470/77190374 (Hg38)
Orient
-
Location type
Intronic
Target gene
TMEM63C
miRNAs that regulate target gene
hsa-mir-4739 ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-185-3p ; hsa-mir-762 ; hsa-mir-5001-5p ; hsa-mir-4498 ; hsa-mir-6781-5p ; hsa-mir-4492 ; hsa-mir-6877-5p ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-5787 ; hsa-mir-765 ; hsa-mir-4505 ; hsa-mir-6081 ; hsa-mir-3192-5p ; hsa-mir-4508 ; hsa-mir-6784-5p ; hsa-mir-1225-3p ; hsa-mir-1233-3p ; hsa-mir-1236-5p ; hsa-mir-1245a ; hsa-mir-125a-5p ; hsa-mir-125b-5p ; hsa-mir-4319 ; hsa-mir-4765 ; hsa-mir-579-3p ; hsa-mir-664b-3p ; hsa-mir-6779-3p ; hsa-mir-7976 ; hsa-mir-8079
Nearest miRNA
hsa-mir-208a/Upstream/2710170; hsa-mir-1185-1/Downstream/75844;
Nearest TSS
ENST00000550708/Upstream/8547; ENST00000557504/Downstream/61335;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/8389, chr14-CpG: 116/Downstream/80016
Upstream sequence
agttttcataaaattctcctccaaaaaaactaaggttcagatcacttctagtttctatcaaacctccaaggcacagataatgccaatgttatttaaactg
Downstream sequence
caccaactacaccaaatcacagagaaagagagattctaaattattctatgaagcacgaacaacatggataccaaaccttgacaaagatagcacaaaaaga
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate