Basic Information
VIS ID
TVIS44028679
Fusion event
HTLV-1-ZNF846 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr19
Cytoband
p13.2
Reference genome
NCBI36/hg18
Start
9750831/9779155 (Hg38)
End
9750831/9779155 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA19B
Target gene
ZNF846
miRNAs that regulate target gene
hsa-mir-6885-3p ; hsa-mir-6772-3p ; hsa-mir-5007-3p ; hsa-mir-584-5p ; hsa-mir-19b-2-5p ; hsa-mir-19b-1-5p ; hsa-mir-19a-5p ; hsa-mir-600 ; hsa-mir-758-5p ; hsa-mir-218-2-3p ; hsa-mir-4262 ; hsa-mir-181d-5p ; hsa-mir-181c-5p ; hsa-mir-181b-5p ; hsa-mir-181a-5p ; hsa-mir-4452 ; hsa-mir-1257 ; hsa-mir-3925-3p ; hsa-mir-766-3p ; hsa-mir-4302 ; hsa-mir-1825 ; hsa-mir-135b-5p ; hsa-mir-135a-5p ; hsa-mir-889-5p ; hsa-mir-199b-5p ; hsa-mir-199a-5p
Nearest miRNA
hsa-mir-1227/Upstream/1389775; hsa-let-7e/Downstream/259199;
Nearest TSS
ENST00000633603/Upstream/10421; ENST00000590046/Downstream/6841;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/10095, chr19-CpG: 69/Downstream/6360
Upstream sequence
ctctgtgcataatatttttcatttgtaaaatgagggttagattaatatccactttctagctctgagggtaaatagttgaataGAATGCTCATGTGAGACG
Downstream sequence
ATTTAACTCTGACATTTCAGCCAACTGTAGCTTCGGGGTGTCACCTTGAAAAGAGGTTGGTTCCTTTGGAAGAAATGTTACTTCCAGAAGTTAGAATAAA
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate