Basic Information
VIS ID
TVIS44028766
Fusion event
HTLV-1-ADD3 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr10
Cytoband
q25.1
Reference genome
NCBI36/hg18
Start
111761787/110012039 (Hg38)
End
111761787/110012039 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
ADD3
miRNAs that regulate target gene
hsa-mir-374b-5p ; hsa-mir-124-3p ; hsa-mir-24-3p ; hsa-mir-23a-3p ; hsa-mir-23b-3p ; hsa-mir-130a-5p ; hsa-mir-374a-5p ; hsa-mir-23c ; hsa-mir-155-5p ; hsa-mir-1202 ; hsa-mir-3972 ; hsa-mir-5006-5p ; hsa-mir-145-5p ; hsa-mir-5692c ; hsa-mir-5692b ; hsa-mir-369-3p ; hsa-mir-129-5p ; hsa-mir-4776-3p
Nearest miRNA
hsa-mir-107/Upstream/5743634; hsa-mir-202/Downstream/886051;
Nearest TSS
ENST00000439456/Upstream/3787; ENST00000473669/Downstream/4396;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/3442, chr10-CpG: 235/Downstream/195631
Upstream sequence
TGTAATGGGTTGTATATATCAAGAATCCTCTAAAACATACAGGTTAGAAGTCTTTCATTGGCTGTTGCTTGAACGAAAAAGTGTGTTATCCCTTAGATGA
Downstream sequence
ATATGATTATTTTTTATTCTTGCAGTAGCTAATTATGGATGTGTGTGTCTATGTATACGTATGTCAAACCATGCTACTTGAGGGATTCTCTTCCTTTTAG
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate